Itsva data kubva kuchirikuenderera Phase 3 kudzidza inotsanangurazve kushanda kweVUMERITY® (Dilosimil fumarate) uye yakagadziridzwa gastrointestinal kushivirira.
Kuenzaniswa neOcrevus® (ocrelizumab), izvo zvakawanikwa zvakaongorora mhando yehupenyu mabhenefiti ane chekuita neTYSABRI® (natalizumab)
Zvimwe zviwanikwa zvehupenyu chaihwo zvinoshuma mabhenefiti akanaka ePLEGRIDY® (peginterferon beta-1a) uye AVONEX® (interferon beta-1a) muvarwere vakura vane multiple sclerosis.
Cambridge, Massachusetts, Gunyana 11, 2020 (Global News)-Biogen Inc. (NASDAQ: BIIB) nhasi yakazivisa data nyowani inoratidzira yakakura kwazvo indasitiri-inotungamira multiple sclerosis (MS ) Kushanda uye kuchengetedzwa kwemusanganiswa wekurapa.Aya data achaunzwa pamusangano wechisere wakabatanidzwa weMSVirtual2020, American Multiple Sclerosis Treatment and Research Committee uye European Multiple Sclerosis Treatment and Research Committee (ACTRIMS-ECTRIMS), ichaitwa kubva Gunyana 11 kusvika 13, 2020.
"Biogen Chief Medical Officer Maha Radhakrishnan, MD, akati: "Biogen inodada nekuti takazvipira kugadzirisa nekukurumidza uye kwenguva refu matambudziko akatarisana nevarwere veMS."Iyo data yatinopa paACTRIMS-ECTRIMS inoburitsa mhedzisiro yakavandudzwa.Yedu yakakura MS chigadzirwa portfolio inoenderera mberi nekushandira varwere vane MS inodzokororwa, zvisinei kuti vari kupi mukurapwa, uye kuenderera kwedu kutsvagisa nekusimudzira Kuisa mukuvandudza kwevanogona kuita zvinodhaka.”
Itsva yeChikamu 3 data inowedzera kuratidza kushanda kweVUMERITY® (Dilosimide fumarate) uye kushivirira kwakataurwa neGI kushivirira.Dhata nyowani kubva kuVUMERITY Phase 3 chirongwa chekiriniki chinotsanangura zvakare Biogen yazvino yemuromo fumarate kurapa Kushanda uye kuchengetedzeka.Kuenzaniswa neTECFIDERA® (dimethyl fumarate) (n = 251) uye kutsigirwa, mhedzisiro yemavhiki mashanu EVOLVE-MS-2 yekudzidza yakasimbisa gastrointestinal (GI) kushivirira kwevarwere vakaongororwa zvine chekuita neVUMERITY kurapwa Kukosha kwekiriniki kwekugamuchira (n. = 253) inovandudza maitiro ayo pamhando yehupenyu hwevarwere vane MS inodzokororwa.Vatori vechikamu muchidzidzo ichi vachitora VUMERITY vakati kashoma kuita zviratidzo zvemudumbu izvo zvinokanganisa zviitiko zvezuva nezuva kana zvine chekuita nekushaya basa, uye kune mishonga mishoma inoshandiswa kurapa zviratidzo zvemudumbu.
Ongororo yekuongorora yekuenderera mberi kweEVOLVE-MS-1 ongororo yakaongorora mhedzisiro yeVUMERITY pakushanduka kwehuropi uye zvimwe zviratidzo zvekiriniki muvanhu vane MS yakadzokera shure (n = 365) inorapwa kweanosvika makore maviri.Ongororo dzakaparadzana dzakaratidza kuti kuderera kwehuropi huzhinji hunogona kunge hwakabatana nekusaziva, kuremara kwemuviri uye kuderera kwehupenyu muvarwere veMS.1,2, data yeEVOLVE-MS-1 inoratidza:
Huwandu hwehuropi hwepagore huwandu hwekuchinja kwevatori vechikamu vakagamuchira kurapwa kweVUMERITY kwemakore maviri hwakafanana nehwevanhu vane hutano.pamwe
Inenge 90% yevarwere vanowana VUMERITY kurapwa havana kusimbiswa kwekuremara kufambira mberi, uye vanenge 84% havana kudzoka mukati memakore maviri.
Iyo yekupedzisira data kubva kuChidzidzo cheChikamu 3 che ENDORSE ichaunzwawo pamusangano, izvo zvinowedzera kuratidza kushanda kwakasimba uye kuchengetedzwa kwakanyatsotsanangurwa kweTECFIDERA muvarwere kusvika kumakore gumi nematatu.
Data chaiyo kubva kuongororo yakaparadzana yehuwandu hweMS hunoratidza kuti kuburikidza neMS PATHS (Partner Advance Technology uye Health Solutions), TYSABRI® (natalizumab), PLEGRIDY® (pegylated interferon beta-1a) Uye AVONEX® (interferon beta-1a) mhedzisiro. vavandudzwa., Biogen iri kushandirapamwe neinotungamira MS nzvimbo muEurope nekuUnited States kugadzira data rakamira, remhando yepamusoro kubva kune dzakasiyana-siyana dzepasi rose dzevarwere veMS.Parizvino, vanopfuura zviuru gumi nezvinomwe varwere vakapinda muMS PATHS.Iyo data yakawanikwa kubva mukurapwa munharaunda chaiyo inotsigira yakagadziridzwa mhedzisiro yakabatana neTYSABRI, PLEGIDYY uye AVONEX.Mhedzisiro yekuongorora kwakasiyana kubva kuMS PATHS data inoratidza:
Mukuenzanisa kwekutanga kweMS PATHS standard magnetic resonance imaging (MRI) regimen, shanduko panguva yenguva yakawedzerwa dosing nguva (EID; n = 85) ye natalizumab yakafananidzwa neuropi yakagamuchirwa MRI (kureva kutevera 0.8 makore).Kamwe chete mavhiki mana (Q4W; n = 569).Ongororo yacho yakashuma hapana misiyano yakakosha muchirwere chitsva cheT2, T2 chirwere chinoshanduka uye uropi atrophy rate.Misiyano yeMRI scanners uye maprotocol ekutora mumakiriniki maitiro anoita kuti kuenzanisa kweuropi MRI kuome.Zvidzidzo zvakawanda zvepasirese zvakaratidza kuti kushanda kwe natalizumab EID kwakafanana neiyo Q4W dose yakabvumidzwa.3-7Biogen inoenderera mberi nekuongorora kushanda, kuchengetedzeka uye kushivirira kwe natalizumab EID kuburikidza neanotarisirwa NOVA kuyedzwa (NCT03689972), uye ichangobva kuendesa chikumbiro che subcutaneous manejimendi kune inodzora masimba.Kana ikabvumidzwa, Ichapa dzimwe sarudzo dzeTYSABRI manejimendi.
Zvinoenderana neNeuro-QoL (Hunhu HweHupenyu muNervous System Zvirwere) ongororo, kurapwa kweTYSABRI kune kuvandudzwa kukuru mune humwe hupenyu hwehupenyu kupfuura Ocrevus® (ocrelizumab).Mukuongororwa kweboka revarwere vakafananidzwa vakarapwa neTYSABRI kana Ocrevus, zvakaonekwa kuti 9 kubva pagumi nemaviri Neuro-QoL madomasi muvarwere vakarapwa neTYSABRI akavandudzwa zvakanyanya (n = 144).4 kunze kwe12 domains yakagadziridzwa zvakanyanya (n = 502)).Pakazere, mwero wepagore wekuvandudza weTYSABRI wakakwira kupfuura weOcrevus, uye misiyano yakakura inocherechedzwa muzvikamu zvitatu: pesvedzero yakanaka uye kugara zvakanaka, kugutsikana nemabasa emagariro uye zviitiko, uye kusagadzikana kwekurara.
Kuenzaniswa nevarwere veMS vari pasi pemakore makumi matanhatu (n = 729), mhedzisiro yekiriniki yevarwere veMS vanopfuura makore makumi matanhatu (n = 286) yakaratidza kuti mumapoka ese ezera, ese PLEGRIDY uye AVONEX anogona kupa anoshanda Iyo kurapa mabhenefiti.Iyo data inoratidza kuti iyo yekumhanyisa kumhanya bvunzo (PST) uye yekusiyanisa sensitivity bvunzo (CST) yemapoka maviri ezera yakavandudza mune rinopfuura gore.Mukuwedzera, vazhinji vatori vechikamu mumapoka ose ezera havana kudzoka mukati memakore maviri.
Dhata kubva kuChidzidzo cheChikamu 1 cheBIIB091 inotsigira kuenderera mberi kurapwa kweMSBiogen, uye data kubva kuChidzidzo chekutanga cheBIIB091 inopihwa zvakare.BIIB091 inosarudza, inodzokororwa (isina-covalent) diki molecule inhibitor yemuromo chiitiko cheBruton's tyrosine kinase (BTK) Agent.Iyo data yakaongorora kuchengetedzeka, kushivirira, pharmacokinetics uye pharmacodynamics yeimwe uye yakawanda inowedzera yemuromo dosi muvanhu vakuru vane hutano.Kusarudza BTK inhibition inogona kubatsira pakurapa kweMS nekudzivirira kushandiswa kwemasero eB uye myeloid masero pasina kupera kwemasero ekudzivirira.
Mharidzo yedata paACTRIMS-ECTRIMS: Ziva: Zvese zviratidziro zveposter zveMSVirtual2020 zvichave zviripo online pa8 AM Eastern Time neChishanu, Gunyana 11, 2020.
Kuenzaniswa neiyo dimethyl fumarate muEVOLVE-MS-2, iyo yakagadziridzwa GI kushivirira kweDiroximel fumarate yakabatana zvakanyanya nekukosha kwekiriniki kwehupenyu hwehupenyu (Poster 0214)
Mhedzisiro yeDiroximel fumarate pahuropi shanduko uye kufambira mberi kwekuremara muvakuru vane EVOLVE-MS-1 relapsing-remitting multiple sclerosis (Poster P0205)
Kuchengetedza uye kushanda kwevarwere vanorapwa ne dimethyl fumarate uye kuteverwa kwemakore gumi nematatu: mhedzisiro yekupedzisira yeENDORSE (platform FC02.05-Svondo, Gunyana 13th 1:48-2:00 US Eastern Time)
Mhedzisiro yeradiology yevarwere vane nguva yakawedzera madosi eNatalizumab haina kusiyana neyakajairwa madhisi enguva muMS PATHS (Poster P0360)
Mhedzisiro yeNatalizumab paHupenyu hweHupenyu mune Chaiyo Cohort yeMultiple Sclerosis Varwere: Migumisiro yeMS Pathway (Poster P1036)
Hunhu uye mhedzisiro yekiriniki yevarwere vakura veMS vane Peginterferon Beta-1a kana intramuscular interferon Beta-1a mukurapa kweMS nzira (Poster P0843)
Chikamu chekutanga cheBIIB091 (a Bruton's tyrosine kinase (BTK) inhibitor) mune vanhu vakuru vane hutano vatori vechikamu: mhedzisiro yekutanga (poster P0186)
Nezve VUMERITY® (Dilosemate Fumarate) VUMERITY ndeye fumarate yemumuromo ine chimiro chemakemikari chakasiyana zvachose kubva kuTECFIDERA® (Dimethyl Fumarate), yakabvumirwa muUnited States kurapwa kwe multiple sclerosis muvanhu vakuru Mafomu echirwere anodzokororwa anosanganisira syndromes yakaparadzaniswa nekliniki, zvirwere zvinowanzoitika uye zvirwere zvechipiri zvinopfuurira.Mushure mekupinda mumuviri, VUMERITY inokurumidza kushandurwa kuita monomethyl fumarate, yakafanana inoshanda metabolite ye dimethyl fumarate.
VUMERITY inopikiswa kune varwere vane allergic kune Diroximel fumarate, dimethyl fumarate kana chero ipi zvayo inobatsira yeVUMERITY;uye varwere vanotora dimethyl fumarate.Izvo zvakakomba mhedzisiro yeVUMERITY yakavakirwa padhata redimethyl fumarate (iyo yakafanana inoshanda metabolite seVUMERITY), kusanganisira allergic reactions uye angioedema, progressive multifocal leukoencephalopathy, inova isingawanzo mukana uropi Utachiona hwehutachiona hunoenderana nerufu kana hurwere hwakanyanya.Kuremara, kuderera kweavhareji lymphocyte count mugore rekutanga rekurapa, shingles uye zvimwe zvirwere zvakakomba, kukuvara kwechiropa uye kuputika.Zviitiko zvinonyanya kurwadza zvakawanikwa uchishandisa data kubva kudimethyl fumarate (ine imwechete inoshanda metabolite seVUMERITY) yaive kuputika, kurwadziwa mudumbu, manyoka, uye kusvotwa.
Ndapota tinya pano kuti uwane ruzivo rwakakosha rwekuchengetedza uye ruzivo rwakakwana rwezvechiremba, kusanganisira ruzivo rwevarwere rweVUMERITY muUnited States.
Nezve TECFIDERA® (dimethyl fumarate) TECFIDERA inzira yekurapa yekudzokorodza multiple sclerosis (MS) muvakuru.Ndiwo mushonga wakanyanya kunyorerwa wekudzorera MS pasi rose.Yakave yakaratidza kudzikisa kudzokorora mwero weMS uye inononoka.Inofambira mberi kusvika pakuremara uye inokanganisa huwandu hweMS brain maronda, uye inoratidza kuti hunhu kuchengetedzwa kwevarwere vane MS yakadzokororwa yakanaka.TECFIDERA yakatenderwa munyika/matunhu makumi matanhatu nepfumbamwe uye yakarapwa kuvarwere 475,000, zvinoreva kuti makore anopfuura 950,000 evarwere vachishandisa nekuraira TECFIDERA.Pane ava, 6,335 varwere (14,241 murwere-makore) vakabva kukiriniki miedzo8.
TECFIDERA inopikiswa muvarwere vasingawirirani nedimethyl fumarate kana chero ipi yezvinobatsira zveTECFIDERA.Zvakakomba mhedzisiro zvinosanganisira allergic reactions uye angioedema, uye zviitiko zvekufambira mberi kwemultifocal leukoencephalopathy (zvisingawanzo mukana wehuropi hwehutachiona hwehutachiona hunoenderana nerufu kana kuremara kwakanyanya) zvakaonekwa muTECFIDERA varwere vane nguva refu lymphopenia, kunyangwe Basa re lymphopenia harina chokwadi mune izvi zviitiko. .Mimwe mhedzisiro yakakomba inosanganisira kuderera kweavhareji lymphocyte count mukati megore rekutanga rekurapa, shingles uye humwe hutachiona hwakakomba, kukuvara kwechiropa uye kutsvaira.Mumiyedzo yekiriniki, zviitiko zvakanyanya kuipa zvine chekuita neTECFIDERA kwaive kubhururuka, kurwadziwa mudumbu, manyoka uye kusvotwa.
Ndapota tinya pano kuti uwane ruzivo rwakakosha rwekuchengetedza uye ruzivo rwakakwana rwezvechiremba, kusanganisira ruzivo rwemurwere rweTECFIDERA yekuUnited States, kana shanyira webhusaiti yechigadzirwa munyika/dunhu rako.
Nezve TYSABRI® (natalizumab) TYSABRI mushonga unoshanda wekudzoreredza multiple sclerosis (RMS), inogona kushandiswa kudzorera MS muvakuru.Miedzo yemakiriniki yakaratidza kuti kurapwa uku kunogona kunonoka kufambira mberi kwekuremara kwemuviri uye kuderedza Kuumbwa kwemaronda matsva ehuropi uye kuderedza kudzokorora.TYSABRI yakabvumidzwa munyika / matunhu makumi masere.Zvinoenderana nemiedzo yekiriniki uye dhata rekunyorerwa, TYSABRI yakagamuchira kurapwa kweTYSABRI kwevanhu vanopfuura zviuru mazana maviri nemazana matatu nemazana matatu pasi rese, vaine makore anopfuura mazana masere nemakumi matatu nemashanu evarwere.9
TYSABRI inowedzera njodzi yeprogressive multifocal leukoencephalopathy (PML), utachiona husingawanzoitiki hwehutachiona hwehuropi hwakabatana nerufu kana kuremara kwakanyanya.Iyo njodzi inowedzera njodzi yePML kuvepo kweanorwisa-JC hutachiona masoja ekudzivirira, kushandiswa kwema immunosuppressive agents uye TYSABRI kurapwa kwenguva refu.Varwere vane njodzi nhatu idzi vane njodzi yakanyanya yePML.Kana uchitanga nekuenderera mberi nekurapa neTYSABRI, vanachiremba vanofanirwa kufunga kuti mabhenefiti anotarisirwa eTYSABRI akakwana kumisa njodzi iyi.
TYSABRI inowedzerawo njodzi yekubata encephalitis uye meningitis inokonzerwa neherpes simplex uye varicella-zoster virus.Sekureva kwemishumo, varwere veMS vanogamuchira TYSABRI vane mhosva dzakakomba, dzinotyisa uye dzinouraya mushure memusika.Munzvimbo yepashure-yekushambadzira, kune zvakare kliniki yakakosha kukuvara kwechiropa, kusanganisira acute chiropa kutadza kunoda kuisirwa.Zvimwe zviitiko zvakakomba zvakakomba zvakaitika muvarwere vakarapwa neTYSABRI zvaisanganisira hypersensitivity reaction (senge allergic reactions) uye kutapukira, kusanganisira hutachiona hwemukana uye humwe hutachiona hweatypical.
Ndokumbira udzvare pano kuti uwane ruzivo rwakakosha rwekuchengetedza, kusanganisira yambiro yebhokisi, uye ruzivo rwakakwana rwemishonga, kusanganisira iyo US TYSABRI dhairekitori remishonga, kana shanyira webhusaiti yechigadzirwa munyika/dunhu rako.
Nezve PLEGRIDY® (pegylated interferon β-1a) PLEGRIDY is subcutaneous pegylated interferon, kamwe chete mavhiki maviri ega ega, nokuda kwechimiro chekare chemultiple sclerosis (MS) muvanhu vakuru, iyo inowanzozivikanwa yeMS.Common fomu.PLEGRIDY parizvino yakabvumidzwa munyika dzinopfuura makumi matanhatu, kusanganisira United States, Canada, Australia neSwitzerland, uye European Union yese.Zvinoenderana nedata rekuraira, vanhu vangangosvika zviuru makumi mashanu nenomwe pasi rese vakawana kurapwa kwePLEGRIDY, vaine makore anopfuura zviuru zana nemakumi manomwe evarwere.10Biogen inoramba ichishanda kuti ipe PLEGRIDY mune dzimwe nyika / matunhu pasi rese.
Kubudirira uye kuchengetedzeka kwePLEGRIDY kunotsigirwa nechimwe chezvidzidzo zvakakura zvakakosha, zvakashandisa interferon therapy mune varwere vane relapsing-remitting MS.Muzvidzidzo zvekiriniki, zvakaratidzwa kuti PLEGRIDY inogona kuderedza zvakanyanya kuwanda kweMS, kunonoka kufambira mberi kwekuremara uye kuderedza huwandu hwekukuvara kwehuropi muMS.Panguva imwecheteyo, zvakaratidzwa kuti kuchengetedzwa kwevarwere vane MS yakadzokororwa kwakanaka.Migumisiro yakataurwa inosanganisira matambudziko echiropa, kusanganisira kukanganisa kwechiropa uye kuwedzera kwechiropa enzymes;kuora mwoyo kana kufunga kuzviuraya;zvakakomba allergic reactions;matambudziko emwoyo, kusanganisira congestive heart failure;autoimmune zvirwere;kuderera kwemasero machena eropa kana platelet kuverenga;uye pfari.Mumiyedzo yekiriniki, zviitiko zvinowanzoitika zvakashata zvine chekuita nePLEGRIDY yaive jekiseni saiti maitiro uye zviratidzo zvakaita sefuruu.Rondedzero yezviitiko zvakashata inogona kuwanikwa mune yakazara PLEGRIDY chigadzirwa label yenyika yega yega inozivikanwa.
Ndokumbira udzvare pano kuti uwane ruzivo rwakakosha rwekuchengetedza uye ruzivo rwakakwana rwekutsanangura, kusanganisira iyo US PLEGRIDY mirairo yekurapa zvinodhaka, kana shanyira webhusaiti yechigadzirwa munyika/dunhu rako.
Nezve AVONEX® (Interferon beta-1a) AVONEX yakagadzirirwa kudzorerazve MS, uye yakatenderwa munyika dzinopfuura makumi mapfumbamwe.Zvinoenderana nedhata yemishonga, vanhu vanopfuura 580,000 pasi rese vakagamuchira kurapwa kweAVONEX, vane makore anopfuura 2.6 miriyoni yemurwere.11AVONEX yakarongedzerwa kurapwa kwekudzokazve multiple sclerosis (MS), kusanganisira kliniki yakasarudzika syndromes, kudzoka-vakuru vane chirwere chinyoro uye chinoshingaira chechipiri chinopfuurira chirwere.
Maererano nemishumo, varwere vanogamuchira AVONEX vane zviratidzo zvekuora mwoyo, pfungwa yekuzviuraya kana psychosis, uye kuwanda kwemhosva dzekuzviuraya kwakawedzera.Varwere vashoma vanorondedzera kukuvara kwakanyanya kwechiropa, kusanganisira kukanganisa kwechiropa.Zviitiko zvisingawanzoitiki zvekusawirirana nazvo zvakashumwa.Kunyange zvazvo beta interferon isina huturu hwemwoyo wakananga, zvinonzi hapana varwere vane ruzivo rwekuzivikanwa vakagadzira congestive heart failure, cardiomyopathy, uye cardiomyopathy ye congestive heart failure.Zvakaitika mushure mekushambadzira zvinoratidza kuti peripheral cell cell count inoderedzwa.Maererano nemishumo, varwere vanoshandisa AVONEX vane pfari, kusanganisira avo vasina nhoroondo yekubatwa.Zvirwere zve autoimmune zvenhengo dzakawanda dzakanangwa zvakataurwa.Zvinokurudzirwa kuita makemikari eropa nguva dzose, hematology, chiropa chinoshanda uye thyroid basa rekuongorora nguva dzose.
Ndapota tinya pano kuti uwane ruzivo rwakakosha rwekuchengetedza uye ruzivo rwakakwana rwekutsanangura, kusanganisira mirairo yekurapa zvinodhaka yeAVONEX muUnited States, kana shanyira webhusaiti yechigadzirwa munyika/dunhu rako.
Nezve Biogen PaBiogen, chinangwa chedu chakajeka: isu tiri mapiyona mumunda weNeuroscience.Biogen inowana, inovandudza uye inopa hunyanzvi hwekurapa pasi rose kune vanhu vanotambura nezvirwere zvakakomba zvetsinga uye zvirwere zveurourodegenerative uye kurapa kwakabatana.Biogen ndeimwe yemakambani ekutanga epasi rose ebiotechnology, yakavambwa muna 1978 naCharles Weissmann, Heinz Schaller, Kenneth Murray, uye vakahwina Mubairo weNobel Walter Gilbert naPhillip Sharp.Nhasi, Biogen ine inotungamira yemishonga portfolio yekurapa kwemultiple sclerosis, yakatanga yekutanga kubvumidzwa spinal tsandanyama atrophy therapy, kushambadzira biosimilars ye advanced biologics, uye yakatarisana nekusimudzira multiple sclerosis uye neuroimmunology.Chirwere cheAlzheimer uye dementia, zvirwere zveuromuscular, kusagadzikana kwekufamba, ophthalmology, immunology, neurocognitive disorders, acute neuropathy uye kurwadziwa.
Isu tinogara tichiburitsa ruzivo rungave rwakakosha kune vanoisa mari pawebhusaiti yedu www.biogen.com.Kuti udzidze zvakawanda, ndapota shanya www.biogen.com uye utitevere pasocial media Twitter, LinkedIn, Facebook, YouTube.
Biogen Safe Harbour Iyi nhepfenyuro ine zvirevo zvinotarisisa kumberi, zvinosanganisira zvirevo zvine chekuita nemabhenefiti angangove, kuchengetedzeka uye kushanda kweVUMERITY, TECFIDERA, TYSABRI, PLEGIIDY uye BIIB091 pasi pezviga zvechiteshi chekuchengetedza zvePrivate Securities Litigation Reform Act of 1995;Migumisiro yeimwe data chaiyo;EVOLVE-MS-2 kudzidza, ENDORSE Phase 3 kudzidza uye BIIB091 Phase 1 mhinduro dzechidzidzo;MS kuzivikanwa uye kurapwa;chirongwa chedu chekuvandudza kurapwa kweMS;zvinogona kutungamira nhaurirano, kuzviisa pasi uye kubvumidzwa uye nguva Urongwa;kugona kwebhizinesi reBiogen rekutengesa, kusanganisira VUMERITY, TECFIDERA, TYSABRI, PLEGRIDY uye BIIB091;uye njodzi uye kusava nechokwadi kwakabatana nekugadzirwa kwezvinodhaka uye kutengeserana.Aya mazwi ekutarisa mberi anogona kushandisa mazwi akadai sekuti "chinangwa", "tarisira", "tenda", "unogona", "kufungidzira", "tarisira", "kufanotaura", "chinangwa", "vavarira", "zvingaite" zivisa.“,” “ronga”, “zvingadaro”, “zvinobvira”, “kuda”, “kuda” nemamwe mazwi nemazwi ane zvirevo zvakafanana.Kuvandudza zvinodhaka uye kutengeserana kunosanganisira huwandu hwengozi, uye nhamba shoma chete yekutsvakurudza uye zvirongwa zvekusimudzira zvinotungamirira mukutengeserana kwechigadzirwa Migumisiro yekuedza kwekiriniki yekutanga inogona kunge isingamiriri mhedzisiro yakakwana kana mhedzisiro yenguva pfupi kana yakakura-yakakura miedzo yekiriniki, uye haigone. vanovimbisa kubvumidzwa kwemitemo.Haufanire kuvimba zvakanyanya pane izvi zvirevo kana data resainzi rakapihwa.
Izvi zvirevo zvinosanganisira njodzi uye kusava nechokwadi, uye zvinogona kuita kuti mhedzisiro chaiyo ive yakasiyana zvakanyanya nemhedzisiro inoratidzwa muzvirevo zvakadaro, kusanganisira asi kwete kugumira pakuitika kwezviitiko zvakashata zvekuchengetedza uye / kana kunetseka kusingatarisirwe kunogona kukonzerwa nedzimwe data kana kuongorora;mari isingatarisirwi kana kunonoka Njodzi;Kunetseka kusingatarisirwi kunogona kubuda nekuda kweimwe data, kuongororwa kana mhedzisiro panguva yekuedzwa kwekiriniki;Kutadza kuchengetedza nekusimbisa dhata redu, kodzero dzezvivakwa zvehungwaru uye humwe muridzi, uye kusavimbika kune chekuita nezvezvichemo zvezvivakwa uye matambudziko;Masangano anodzora anogona kuda rumwe ruzivo kana kumwe kutsvagisa, kana kusakwanisa kubvumidza kana kunonoka kubvumidzwa kwevanoda zvinodhaka kana kuwedzera kwemazita echigadzirwa;kukundikana kuwana mvumo yekutonga mune dzimwe nzvimbo;zvichemo zvemhosva yechigadzirwa;yechitatu-bato kubatana njodzi;uye Denda ririkuenderera mberi reCCIDID-19 rine mhedzisiro yakananga uye isina kunanga pabhizinesi redu, maitiro ekushanda uye mamiriro emari.Zvizhinji asi zvisiri zvese zvezvinhu zvakanyorwa pamusoro zvinogona kuita kuti mhedzisiro chaiyo isiyane netarisiro yedu mune chero zvirevo zvinomirira mberi.Vagadziri vemari vanofanirwa kufunga nezve iyi yambiro uye nezve njodzi dzatakaona mushumo yedu ichangoburwa yegore kana yekota nemimwe mishumo yatinoisa kuSecurities and Exchange Commission.Izvi zvirevo zvinoenderana nezvatinotenda uye zvatinotarisira uye zvinomiririra chete mamiriro kubva pazuva rekuburitswa kwenhau.Zvingave zvichikonzerwa neruzivo rutsva, zvichaitika mune ramangwana kana zvimwe zvikonzero, hatitore chisungo chekuvandudza pachena chero zvirevo zvinomirira mberi.
Mowry EM, Beheshtian A, Waubant E, etc. Unhu hwehupenyu mu multiple sclerosis hunobatana nechirwere chechirwere uye zviratidzo zvekuyera kwehuwandu hwehuropi.Neurology.2009;72(20):1760-1765.
Lanz M, Hahn HK, Hildebrandt H. Brain atrophy uye kukanganisa kwekuziva mu multiple sclerosis: kuongorora [Kugadziriswa kwakabudiswa kunobudiswa muJ Neurol.2008 Feb;255(2):309-10].Nyaya yeNeurology.2007;254 Wedzero 2: II43-II48.
Foley J, Xiong K, Hoyt T, etc. Chiyero chakapfava cheserum neurofilament muvarwere vane relapsing-remitting multiple sclerosis yakashandurwa kubva ku natalizumab kamwe chete pamavhiki e4 kusvika kune yakawedzera nguva yekutonga.AAN 2020;S10.009.
Butzkueven, Kappos L, Spelman T, etc. Varwere vakachinjira ku natalizumab kwekuwedzera nguva yedosing kana kuchengetedza yakajairwa interval dosing vaive vasina mutsauko wakakura mumibairo yekudzokorodza: ​​kuenzanisa kunobudirira kuongororwa kwenhamba yevarwere muchirongwa chekutarisa cheTYSABRI.ECTRIMS 2019;P1033.
Yamout B, Sahraian MA, Ayoubi NE, zvichingodaroMult Scler Relat Disord.2018;24:113-116.
Zhovtis Ryerson L, Frohman TC, Foley J, etc. Kuwedzerwa nguva yekutonga kwe natalizumab mu multiple sclerosis.J Neurol Neurosurgery Psychiatry.2016;87:885-889.
Bomprezzi R, PawateS.Yakawedzerwa nguva dosing ye natalizumab: 7 makore echiitiko munzvimbo mbiri.Ther Adv Neurol Disord.2014;7:227-231.
Kubva munaChikumi 30, 2020, zvichibva pane yakasanganiswa-yekutengesa-data kubva kukiriniki kuyedzwa kwekunyorerwa uye kuratidzwa kune TECFIDERA.
Kubva munaChikunguru 31, 2020, yakasanganiswa mushure mekutengesa data zvichibva pane zvakatemwa uye miedzo yekiriniki yekuratidzwa kweTYSABRI.
(Bloomberg) -SAP SE mutengo wemari wakawira kusvika ku21%, iyo yakakura yezuva rimwe chete inodonha kubva muna 1999. Kare, kambani yeWalldorf-based yakaderedza mari yaro yegore rose uye yakati inotarisira kutenderera kutsva kwemari.Yakakiyiwa kusvika hafu yekutanga ya2021, kudiwa kwakaderedzwa.Mukuedzwa kwaChristian Klein, akazove CEO akasarudzika muna Kubvumbi.Denda iri richanonoka mari yeSAP yegore, kutengesa kwese uye kushanda purofiti kwegore kana maviri, kunyanya sekutaura kwakaita kambani yesoftware mukutaura neSvondo.SAP yakataura kuti inotarisira kukura kushoma uye purofiti mumakore maviri anotevera, uye ichafambisa hurongwa hwayo hwe2023 kusvika 2025. Klein akati mumusangano wekufona neMuvhuro kuti anotarisira kuti SAP itaure mukutaura kuti maonero apfuura "anofungidzira kuti hupfumi huchavhurika zvakare uye kuvharirwa kwevanhu kuchadzikama, zvichikonzera kuvandudzwa zvishoma nezvishoma munzvimbo inodiwa muchikamu chechitatu nechina. "Iyo kambani ichangobva kufanotaura kuti panosvika 2020, zvichienderana neyakagadziriswa mitengo yekuchinjana, mari yakagadziridzwa ichasvika 27.2 bhiriyoni euros kusvika 27.8 bhiriyoni euros (32.2 bhiriyoni kusvika 32.9 bhiriyoni US madhora), iyo yakaderera pane yaitarisirwa uye yakawedzera kusvika 28.5 bhiriyoni euros kubva kukutungamira kwekare. ye27.8 bhiriyoni euros.Euro.SAP yakataurawo kuti bhizinesi rayo reConcur harichabatsiri nemari ine chekuita nekufamba gore rino.OddoBHF muongorori Nicholas David akanyora mumushumo kuti zvakaoma kuwana mimwe mibairo yakanaka kubva mumhedzisiro Nhau.Zvinotarisirwa nemusika zvezvishuwo zvepakati-temu zviri / kutya, asi zvishuvo zvitsva zvakaderera pane zvinotarisirwa zvakanyanya. "Qualtrics IPOSAP yakati yayo Qualtrics software chikamu chiri padanho repamusoro rekunyorwa.Yakazivisa muna Chikunguru kuti yakafunga kutora kambani nemutengo werekodhi uye yakaenda kuruzhinji muUS mukati memakore asingasviki maviri.Uku kwaive kutendeuka kwaisatarisirwa uye kwakaratidza shanduko yehungwaru pasi pehutungamiriri hwaKlein."Isu tafambira mberi mukugadzirira Qualtrics 'IPO," Chief Financial Officer Luka Mucic akadaro parunhare neMuvhuro."Qualtrics 'yakasimba kuita kwekota kuchaisa hwaro hwekuwedzera kukura gore rinouya."Maonero matsva akagadziridzwa mari yegore anotarisirwa kuwedzera kubva pamabhiriyoni masere emadhora kusvika pamabhiriyoni masere nemazana maviri emadhora muna 2020, yakaderera pane fungidziro yapfuura yemabhiriyoni masere nemazana matatu emadhora.Mari yekushanda kweEuro gore rino ichange iri pakati pe8.1 bhiriyoni maEuro ne8.5 bhiriyoni maEuro, inova yakaderera pane yaitarisirwa 8.7 bhiriyoni maEuro.SAP yakawedzera chinangwa chayo chepakati-temu kudarika 36 mabhiriyoni eEuro mumari yose ne2025 uye ichasvika 35 mabhiriyoni eEuro ne2023.Isiri-IFRS yechitatu-kota yekushanda purofiti mukota yechitatu yakadonha 12% gore-pa-gore kusvika 2.07 bhiriyoni euros.Zvichienzaniswa ne2.15 bhiriyoni euros inotarisirwa nevanoongorora vakaongororwa neBloomberg, mari yekuwana panguva iyi yakadzikira ne4% kusvika 6.54 bhiriyoni euros, nepo avhareji yekufungidzira yaive 6.89 bhiriyoni euros., SAP CEO kuburikidza nePandemicU.K.Iyo CMA inodhirowa nzira yayo uye inotanga kuferefeta kunopesana neSinch, chikamu cheSAP DealSAP chinopfuudzwa kuna JP Morgan Stanley, uye JP Morgan anoitisa Qualtrics IPO (stock updates, mamwe mamiriro).Ndokumbira ushanyire Bloomberg.com kutishanyira uye unyore izvozvi.Chengetedza chinzvimbo chinotungamira seyakanyanya kuvimbika sosi yenhau dzebhizinesi.©2020 Bloomberg LP
Akaundendi weSan Francisco akakurukura nezvekukosha kwehutongi hweBiden kune mari yekudyara muhurukuro dzese nevatengi.
Vashandisi vasina kuisa odha pane chero puratifomu yeJD vanogona kugamuchira kuderedzwa makuponi!Nekadhi rako reVisa, tinya kubhadhara kuJD.com kekutanga uye unakirwe nemitengo!
Mubairo weNobel mune zvehupfumi, purofesa weYale University Robert Shiller akakurudzira vanoisa mari kuti vangwarire nezve blockbuster stock market mune ichangoburwa muNew York Times.
Kambani iyi yakati Lee Kun-hee, akavaka Samsung Electronics kuita hofori yepasi rose mune smartphones, semiconductors uye maTV, akafa neSvondo mushure mekuiswa muchipatara kweanopfuura makore matanhatu nechirwere chemoyo neSvondo.Lee ane makore makumi manomwe nemasere ekuberekwa gore rino.Akagadzira Samsung Boka kuita gungano rakakura kwazvo muSouth Korea uye akave murume akapfuma muSouth Korea.Jeong Sun-, CEO wekambani inotsvagisa kambani Chaebul.com, akati: “Kusimuka kunoshamisa kwaLee muKorea uye masanganisiro akaita South Korea mukudyidzana kwenyika dzepasi pose anofananidzira zvekuti rufu rwake ruchayeukwa nevakawanda vekuKorea.
Makore mana mushure mekudonha kweBHS, indasitiri yekuongorora yakashoropodzwa nekutadza kuwana chero matambudziko yachinja here?
Sekureva kweCNBC mishumo, Jack Ma, muvambi weAlibaba Group Holdings Limited (NYSE: BABA), akataura neMugovera kuti Ant Group's maviri ekutanga veruzhinji zvipo (IPOs) muShanghai neHong Kong ichava kambani hombe yepasirese Yakanyorwa.Zvakaitika: CNBC yakataura kuti IPO mutengo waive Chishanu manheru, asi Jack Ma haana kuburitsa iyo chaiyo nhamba, iyo ichaziviswa svondo rinouya.Nhoroondo yevanhu-yakatemerwa kunze kweNew York City."Ma Yun akadaro kuShanghai Bund Summit.MuchiChina bhirioni akadana nyaya iyi "chishamiso."Akati: “Hatina kumbofunga nezvazvo makore mashanu kana kuti matatu apfuura."Ma Yun akadaidzirawo shanduko yemabhanga uye kuti pave nehurongwa hutsva hwekubhanga hwepasirese.Nei zvichikosha: Zvipo zvekutanga zveveruzhinji zvemakambani anotsigirwa neAlibaba zvinogona kuburitsa mari inosvika bhiriyoni imwe chete, izvo zvinozoita kuti ive Saudi Aramco Iyo yakapfuura yakakura yepasirese yekutanga kupa veruzhinji yeUS $ 29.4 bhiriyoni.Aramco stock yakapihwa muna Zvita 2019 yakakunda Alibaba uye yakahwina korona yeiyo yakakura IPO.Sekureva kwemishumo, homwe yehupfumi yeSingapore GIC Private Limited inogona kunyorwa mune idzi mbiri zvinyorwa.Mari iyi inodarika US$1 bhiriyoni.Sekureva kweReuters, Temasek wekuSingapore, muchengeti weAnt aripo, aratidzawo kufarira muzvitoro.Mutengo chiitiko: Alibaba mutengo wemasheya wakavhara kusvika 1.2% neChishanu kusvika US $ 309.92.Yakakwira ne0.11% panguva yekutevera-maawa ekutengesa chikamu.Zvimwe zvibvumirano kubva kuBen Singa * Tinya apa kuti uone sarudzo yaBen Singa * Quibi inodonha-iyi pfungwa haina kusimba zvakakwana, Benzinga.com hutungamiriri (C) hwakati muna 2020: "Kana "Nguva" haipo.Benzinga haipe mazano ekutsvaga mari.kodzero dzose dzakachengetedzwa.
Ipai pakarepo kuti mutsigire sangano revapoteri reUN, kuitira kuti vapoteri vawane zvigadziro zvekukurumidzira kuti vatarise nguva yekunaya uye kuvaponesa kubva kune njodzi!
Zviri nyore kutenga masheya, asi zvakaoma kutenga masheya akakodzera pasina chirongwa chakaedzwa-nguva.Saka, ndeipi stock yakanakisa kutenga kana kuisa pane yekutarisa rondedzero izvozvi?
Ramangwana rakadonha zvakanyanya.Musika wemasheya unogona kuenda nevatungamiriri vakaita seMicrosoft uye Tesla.Nesarudzo dzaiswedera uye nyaya dzekoronavirus dzakawedzera, iri raive svondo repamusoro remari.
Harry Markopolos (Harry Markopolos), aimbova derivatives nyanzvi akatendeukira kune yakazvimirira yehutsotsi muongorori, akawana $ 65 bhiriyoni Bernie Madoff Ponzi chirongwa, asi akafuratirwa neSEC Kwemakore mapfumbamwe.Semutsoropodzi akajeka wevatongi veUS, Harry ikozvino anoona ndima yekuongorora uye indasitiri yeinishuwarenzi senyaya huru inotevera yekubiridzira kwemari kuburitswa.
Hang Seng's new online tax-deductible annuity inopa makore gumi ekuwedzera yakagadziriswa mari uye inovimbisa 1.73% -2% yekumisikidza mari yemukati.Zvinongotora anenge maminetsi gumi kunyorera inishuwarenzi online uye kuita nekukurumidza.
Vanhu vatatu vanoziva nezvenyaya iyi vakati iyo iPhone's top assembler, Taiwan-based Foxconn, yakamisa boka rinoshanda kuti rirambe kupesvedzera kuri kukura kwemugadziri wemagetsi weChinese Luxshare.Iyo kambani inotenda kuti Luxshare inoumba hutongi hwayo.kutyisidzira kwakakomba.Imwe yezvinyorwa yakati chirongwa ichi chakatangwa naFoxconn muvambi Guo Taiming uye chinangwa chiri Luxshare <002475.SZ> ine muzinda kuDongguan.Iyo kambani inozivikanwa zvishoma pasi rose, asi inotarisirwa kuve kambani yekutanga kuungana muChina.Hofisi ye iPhone-kusvika izvozvi, turf ichiri kutungamirwa nevagadziri veTaiwanese.Tsime rakati boka rekushanda rakavambwa gore rapfuura uye rave kuongorora tekinoroji yeLuxshare, hurongwa hwekuwedzera, zano rekutora uye kana kambani (ikozvino inongotora 5% yemari yeFoxconn) inotsigirwa nechero hurumende yeChina.
Svondo rino mihoro mikuru uye hupfumi data data ichaburitswa gare gare svondo rino, uye akawanda maFAANG stocks anoshumwa mushure mekuvhara neChina.
AMD (AMD) mushumo wechitatu wekota yemuhoro wakarongerwa kuburitswa mushure mekuvhara neChipiri, inova nguva inonakidza yeindasitiri yesemiconductor.Iyo Wall Street Journal yakataura kuti AMD (AMD) inoronga kushingaira kuwedzera bhizinesi rayo kuburikidza neanogona kutora (XLNX) (XLNX).Panguva imwecheteyo, mukwikwidzi wayo mukuru (INTC) anga achishanda nesimba kuti arambe achigadzira matekinoroji ekugadzira epamusoro anodiwa kugadzira emhando yepamusoro semiconductors.
Tenga pazvitoro zvikuru zvefashoni yepamhepo uye shandisa kadhi reVisa kuti unakirwe kusvika pa20% kubva!Tsvaga zvichangobva kuunganidzwa zveLuisa Via Roma uye Taylor izvozvi!
Muongorori weCFRA Garrett Nelson akataura mubvunzurudzo neYahoo Finance neChishanu kuti kana Joe Biden (Joe Biden) akakunda musarudzo yemutungamiri wenyika, Tesla (NASDAQ: TSLA) ndiye achakunda zvakanyanya.Zvakaitika: Nielsen akataura kuti Tesla ichave "imwe yemakambani makuru" anokunda nekuti kambani iyi "yakachena mota yemagetsi."Muongorori uyu akataura kuti hurumende yeBiden ichapa rubatsiro rwakakura kumotokari dzemagetsi.CFRA Vaongorori vakaratidza kuti VaBiden vakakurudzira "kuwedzera kukuru kwemitero yemotokari yemagetsi" uye "kuvaka kukuru kwezviteshi zvekuchaja mota dzemagetsi."Nielsen akati: “Muri kufunga kuwedzera nhamba yezviteshi zvekuchaja motokari dzemagetsi nekanenge ka20.Ichabatsira chaizvo kufarirwa kwemotokari dzemagetsi."Zvakakosha: Munguva yekupedzisira gakava remutungamiri wenyika muTennessee svondo rapfuura, Biden akati hurumende yake ichadyara zviuru makumi mashanu zviteshi zvekuchaja mota mumugwagwa mukuru.Vanokwikwidza vanoti zviteshi zvekuchaja izvi zvichatungamira United States kuve ne "ramangwana."Aimbova mutevedzeri wemutungamiri anotenda kuti chiono chake chemotokari dzemagetsi chinogona kugadzirisa kushanduka kwemamiriro ekunze uye kugadzira "mabasa matsva anobhadhara zvakanyanya."Iyo kambani inotungamirwa naElon Musk yakazivisa chikamu chechitatu svondo rapfuura Revenue yaive US $ 8.77 bhiriyoni, kuwedzera kwe39% gore negore;Mutengo chiito: Tesla migove yakavharwa neinoda kusvika 1.2% neChishanu kusvika US $ 420.63.Kana Joe Biden akahwina iyo TSLA DateFirmActionKubva ichangoburwa musarudzo dzaGumiguru 2020 Ratings Morgan Stanley anochengetedza huremu hwakaenzana (Gumiguru 2020) Canaccord Genuity inochengetedza kutengeserana kwakaitwa muna Gumiguru 2020 uye inokunda musika wakakura zvisina kwayakarerekera.Ona mamwe ma analyst ratings eTSLA.Ona ichangoburwa muongorori ratings* Kuongorora kwazvino kwaBenza kwekutengeserana * Rives Musk akati masevhisi epamwedzi ekurenda achavepo gore rinouya.Jim Kramer akataura kuti Jim Tesla "anopenga stock" muna 2020 (C) Benzinga.com, iyo "yakaipa" Benzinga haina kupa zano rekudyara.Kodzero dzese dzakachengetwa.
Ndeipi nzira yekudyara yakamira muedzo wenguva?Kukura mari.Nyanzvi dzeWall Street dzinotenda kuti masheya ane tarisiro yekukura zvakanyanya anoratidza mamwe emasheya anomanikidza.Uku kugona kwekukura kuri kupfuura zera razvino, uye mazita aya achawana madzoro akakura muna 2020 nekupfuura.Izvo zvakati, kutaura zvishoma, kutsvaga masheya anowira muchikamu ichi kunogona kuve kwakaoma.Vaongorori vanotenda kuti imwe nzira ndeyekutora danho kumashure, kutarisa mufananidzo mukuru, uye kutarisa kumakambani ane kukura kwenguva refu kunoenderana nezvinokatyamadza zvakabudirira gore-kusvika-zvino.Tichichengeta izvi mupfungwa, takashandisa dhatabhesi reTipRanks kuona matatu ekukura masheya ayo akayerwa zvakanyanya nevanoongorora.Ese mastock matatu akawana kukura kwakanyanya muna 2020 uye akagadzirira kuramba achikwira.Pennsylvania National Game Company (PENN) Chekutanga, isu tiri vePennsylvania National Game Company, muridzi nekushandisa zvivakwa zvemitambo nemijaho uye mabhizinesi emitambo yemavhidhiyo muUnited States.Iro zita rakakwira ne146% gore-kusvika-zuva, asi vamwe vaongorori veWall Street vanotenda kuti kuchine mafuta akawanda mutangi.PENN nguva pfupi yadarika yakazivisa mhedzisiro yayo yekota pamberi, iyo yakapfuura zvaitarisirwa.Iyo kambani inotarisira purofiti yekota kuti iwedzere neinopfuura mazana mapfumbamwe mapoinzi, uye yakagadziridzwa EBITDAR ichakura ne5% gore-pa-gore, kunyangwe mari yakadzikira gumi% gore-negore.Muongorori wenyeredzi shanu Joseph Greff akaudza vatengi kuti "JP Morgan Chase" akati: "Kudzoreredza kweindasitiri yemitambo yedunhu muna Chivabvu/Chikumi kwakaenderera mberi kusvika kota yechitatu, uye mari yakawanikwa iri nani pane zvaitarisirwa.Pakangotsikirirwa kudiwa Mushure mekudzoka kune zvakajairwa, uye sezvo yakapfuura COVID kunyatsoshanda kwave nani, mari yekushandisa haina kana kukwira.Isu takambofungidzira kuti kukura kwakaderedzwa. "Ataura izvozvo, Greif akabvuma kuti nekutariswa kwemutengo wemasheya, vamwe vanoongorora vanga vachisiya kuderedzwa kumashure.Nekudaro, iye achiri kutenda kuti "kukosha uye catalyst yeramangwana".Vanoongorora vanoti: “…Pane kukandirana makobvu nematete mumanzwiro evanodyara mari.Isu tinotenda izvi zvine hutano kune masheya uye zvinenge zvakafanira kuti masheya arambe achikwira;isu tinotenda kuti echinyakare equity vatengesi vemitambo havana kushungurudzwa zvachose.Isu tinotenda kuti vanoisa mari havana chokwadi nekugona kwePENN kukwikwidza neDraftKings, Fanduel, Caesars Entertainment, MGM/GVC, nezvimwewo. PENN's hama yeshizha reshizha saizi inogona kubhadhara mari yekutenga yevatengi vekutanga kubheja kwemitambo, asi isu tinotenda, Tichifunga kuti kuenzana kwazvino kuunganidza mari kwakakwidza $950 miriyoni, njodzi yemakwikwi aya yakaderedzwa mukati mechikamu chine musoro. "Kunyanya kukosha, PENN nguva pfupi yadarika yakatanga iyo Barstool Sports kubheja app muPennsylvania.Greff akadana kuburitswa uku kwekutanga "kukurudzira maererano nehuwandu uye kushandiswa kwekushambadzira," uye zvakaratidza "mukana wenzira yakasarudzika yekuwana mugove."Mukuwedzera, kukurumidza kweBarstool Sportsbook kuri kuwedzera.Zvinotonyanya kukosha, Greff anotenda kuti ikozvino mitambo yekubheja uye iGaming nharaunda yakafanana nekukwira kwemisika yedunhu muma1990, apo nyika dzine kushomeka kwebhajeti dzakatendeukira kune mitsva yemari, senge rwizi mitambo yekubatsira kubhadhara mabhajeti avo.deficit.Panyaya iyi, muongorori uyu akati: “Tinotenda kuti nyika yega yega ine tarisiro dzakafanana dzeUSSB neGaming, uye PENN ichava mumwe wevakundi.Isu tinoda iyo nyika-yakavakirwa mutambo / mitambo kubheja / iGaming pateni muUS uye tinoona nzvimbo yekukura..”Hameno hazvishamise kuti Guva rakagara naMabhuru.Mukuwedzera pakupa "kurema" chiyero, akaisawo mutengo we $ 83 wemari.Kana chinangwa ichi chikazadziswa mukati memwedzi gumi nembiri inotevera, vanoisa mari vanogona kuwana 32% yekudzoka.(Kuti uone rekodhi yaGreif, tinya pano.) Ko imwe Wall Street yese inoti kudii?Zvipfumbamwe kutenga, zvitatu zvakabata uye imwe yekutengesa zvakapihwa mumwedzi mitatu yapfuura.Nekuda kweizvozvo, PENN yakagamuchira "yepakati kutenga" kubvumirana chiyero.Zvichienderana neavhareji yemutengo we $ 76.77, mutengo wemari unogona kukwira ne22% gore rinouya.(Ona Penn National Gaming stock analysis paTipRanks.) Redfin (RDFN) Redfin yakatanga nemepu-based search space uye yakawedzera zvigadzirwa zvayo kuti iite mitambo yemhuri, debuts uye kugadzirisa maitiro nekukurumidza uye nyore.PaWall Street, vamwe vanhu vanofunga kuti zita racho haringori nezvekuvhiya kweCCIDID, uye kuwana kwayo 113% gore-kusvika-zuva ndiko kutanga.Kunyangwe RDFN yakabvisa fungidziro yakasimba yechitatu-kota, vanoisa mari vakaodzwa mwoyo nemhedzisiro.BTIG's Jake Fuller akataura kuti mutengo wemasheya unogona kudonha nekuti "tarisiro yakakwira uye kuwedzera kuri pakati nepakati muchiyero chemari inenge 2%" uye "vanodyara mari vanowanzo kupa mubairo-inotungamirwa rhythm, nepo RDFN ichisara kumashure kwetarisiro iyi."Fuller anotenda kuti RDFN haisi iyo inotariswa nevanhu vazhinji, izvo zvinoratidza kuti vanoisa mari vanogona kunge vasina kuona kuburitswa kwemari.Nekudaro, anofunga Wall Street inogona kupotsa chikamu chakakosha chepuzzle.Muongorori wenyeredzi shanu akati: "Chinogona kufuratirwa pano ndechekuti RDFN yakawedzera mwero wekomisheni pasina kukanganiswa kweshanduko, izvo zvinosimudzira zvikuru maonero eRDFN's gross purofiti."Kuti izvi zviitike, achaita Iyo 2021 gross purofiti inotarisirwa kuwedzera ne47%.Tichinyatsotarisa ruzivo rwakadzama rwekota, RDFN yakaona kudiwa kwakasimba uye mari yezvivakwa zvedzimba yakakura 36% gore-pagore.Webhusaiti traffic uye vhoriyamu yekutengeserana yakawedzerawo mwedzi-pa-mwedzi.Zvisinei, zvinofanira kucherechedzwa kuti kumusoro kunotungamirirwa nemari yekutengeserana kwega kwega.Fuller akati: "Izvi zvakakosha nekuti zvinoratidza kuti mwero wekomisheni unotarisirwa unozopedzisira wabatsira.""Maererano nehuwandu hwedu, mari yezvivakwa zvekutengesa zvivakwa kubva pa1.68% yeGTV muchikamu chechitatu cha2019 uye chikamu chechipiri che2020 1.78% yakawedzera kusvika inofungidzirwa 1.85% muchikamu chechitatu cha2020. traffic yakawanda munzvimbo ino.Kunyangwe zvakaoma kuongorora kuenderera mberi kwechido, kukwira kwemitengo uye mari yepurofiti iri nani inofanira kuramba yakagadzikana "Fowler akataura.Zvichienderana netarisiro yake, Fuller akatsigira mabhuru, achidzokorora mutengo wekutenga uye mutengo wemasheya wemadhora makumi matanhatu nemashanu.Ichi chinangwa chinoratidza chivimbo chake mukukwanisa kweRDFN kuwedzera ne45% gore rinouya.(Kuti uone rekodhi yaFuller, tinya pano.) Pakutamira kune dzimwe nzvimbo dzeWall Street, pfungwa dzakatonyanya kupatsanurwa.Mumwedzi mitatu yapfuura, 6 inotenga, 5 inobata uye 1 kutengesa yakagoverwa.Sekureva kweWall Street, RDFN iri pakati kutenga.Ivhareji yemutengo inotarirwa yemadhora makumi mashanu inoreva 11% kumusoro.(Ona Redfin stock analysis paTipRanks) Vertiv Holdings (VRT) Seimwe yepasirese inotungamira hardware, software nevanopa masevhisi, Vertiv Holdings yakabatsira kusimudzira musika wakabatana wedhijitari masisitimu, umo nhamba huru inodiwa Iyo data inoda kufambiswa, kuongororwa, kugadziriswa uye kuchengetwa.Wall Street yakati yakakwira 71% kusvika zvino gore rino, uye panogona kunge paine zvimwe zvakawanikwa.Kunyangwe kana mutengo wematengo uchikwira zvakanyanya, Wolfe Research muongorori Nigel Coe achiri kutenda kuti njodzi / mubairo mamiriro akanaka.Akatsanangura kuti: "Tinotenda kuti Vertiv imhando isingawanzo kukwezva vatengesi vakasiyana-siyana: kambani inokura zviri pakati nepakati iyo inogona kupa purofiti inoyevedza pamutengo wakaderera uye iri pasi pebasa rechikwata chepamusoro."Kana zvasvika kuVRT Panzira yekukura, misika yayo mikuru yekupedzisira inzvimbo dzedata uye nharembozha.Idzi nzvimbo inzvimbo idzo Coe anotarisira kuwana kukura muna 2020 uye 2021, pamwe nekukanganisa kwenguva refu kwenguva refu kwakaunzwa nekuwedzera kunoramba kuripo kwe data rakasimba uye 5G kukwidziridzwa.Pamusoro pezvo, vachisundwa nekuedza kuchengetedza mitengo yakatarwa nguva dzose kuburikidza nekusimudzira kwakasiyana-siyana kwekuita uye kuderedza kuomarara kwesangano, manejimendi akatsanangura nzira yekuwedzera purofiti kusvika ku500 mapoinzi."Iri script rakabudirira kutumirwa nasachigaro mukuru David Cote panguva yaaive ari kuHoneywell, izvo zvinoita kuti titende kuti zvinyorwa zvakafanana zvinogona kuiswa muVertiv," akadaro Cohen.Zvakakosha kucherechedza kuti VRT yakabuda muchikamu chechipiri cha2020, iine chikwereti chinosvika mabhiriyoni maviri nemazana maviri emadhora uye net chikwereti/EBITDA chasvika ka4.2.Kunyangwe pamucheto wepamusoro weiyi renji, Coe anotenda kuti bharari rinogona kukurumidza kukurumidza.Kuti izvi zviitike, anofunga kuti panosvika 2023 muyero wechikwereti / EBITDA kaviri, ipapo capital yakasara ichasvika bhiriyoni imwe US ​​dollar."Parizvino isu hatifunge kuti Vertiv inyaya yakajeka yekuendesa mari, asi izvi zvinogona kuitika mukati menguva ye2022/23-tinogona kuona zviitiko zvekutora kusimudzira kugona kwayo mumunda wekugovera magetsi uye DCIM layer.Dzimwe sarudzo dzinogoneka dzinosanganisira kuvharwa kwemawaranti emari (aya ari kuratidzwa pari zvino mukuverengerwa kwedu kwakadzikiswa kuverengerwa chikamu) uye nzira iyo migove inogovaniswa nayo, inozowedzera mukana wekuva muridzi wesangano.Isu zvakare hatigone kufuratira chokwadi chekuti akawanda mahombe emagetsi emagetsi Chikamu chekudyidzana kwakagadzwa nevatori vechikamu pamusika, ava vatori vechikamu havasi vatori vechikamu vakakosha munzvimbo yedata. "Zvese zvakaitwa neVRT zvakanyengetedza Coe kuti adzokorore mwero wayo wepamusoro.Paanenge achidana sarudzo, akaisa mutengo wemutengo wemadhora makumi maviri nematatu, zvichireva 22% kumusoro.(Kuti uone nhoroondo yaCoe, tinya pano) Vamwe vaongorori vanobvumirana here?vari.Mumwedzi mitatu yapfuura, 4 chete chaiyo "kutenga" ratings yakabudiswa.Naizvozvo, meseji iri pachena: VRT kutenga kwakasimba.Zvichipa kuti muvhareji wekutengesa mutengo ndeye $ 20.75, mutengo wemari unogona kukwira ne10% gore rinouya.(Ona Vertiv Holdings stock analysis paTipRanks) Disclaimer: Maonero anotaurwa muchinyorwa chino ndeaya chete emuongorori mukuru.Zviri mukati ndezvekureva chete.Usati waita chero mari, zvakakosha kuti uite yako ongororo.
Microsoft, Apple, Alphabet, Facebook, Amazon, AMD, Caterpillar, Comcast, GE, Ford, Pfixer, Visa, UPS, Exxon Mobil, Twitter nemamwe makambani akashuma mhedzisiro yavo yekota yechitatu.
Nzvimbo itsva yekugovana yeHong Kong SMEs- "HSBC Airport" inokubatanidza iwe kune akasiyana bhizinesi ruzivo nezviitiko
Musvondo rinopera Gumiguru 22, mari dzemubereko dzemumba dzakadzika kusvika pakudzikira.Zvinotarisirwa kuti COVID-19 neAmerica zvematongerwo enyika zvicharamba zvichiita svondo rino.
Trifecta Stocks icharatidza mabearish stocks Chitatu chega chega, uye panogona kuve nemikana inonakidza yekudyara mikana munguva pfupi.Tichishandisa tekinoroji yeaya machati emasheya, uye pazvinenge zvakakodzera, zvichibva pane zvichangobva kuitika zveTheStreet's Quant Ratings uye zviyero, takabvisa mazita mashanu.Kunyangwe isu tisingatarise kuongororwa kwakakosha, isu tinovimba kuti chinyorwa ichi chichapa vanoisa mari vanofarira mumasheya nenzvimbo yakanaka yekutanga yekuwedzera basa rechikoro pazita.
Mushure memakore ekushanda paAmerican shale gasi, Chevron iri kubheja remangwana rayo gasi rechisikigo munharaunda isina kugadzikana yeMiddle East, uye vashandi vesimba vagara vakangwarira.Mukuru wekambani Michael Wirth danho rakasarudzika rinotsigirwa nebheti yekuti Middle East yave kupinda munguva yekuyananisa, izvo zvinozoita kuti ive sarudzo yakanaka yekuchera gasi rechisikigo, sezvo inotarisirwa kunge isingadhure pane yakachipa uye yakachena mafuta.Kudiwa kuchapfuura mafuta.Iro zano idzva nderekuti kambani inosimudzira kutsva kwegasi rechisikigo kuEgypt, Israel, neQatar, uku ichideredza kushandisa mari pakuongorora shale muUnited States.